Drug makes hearts repair themselves

A drug that makes hearts repair themselves has been used in research on mice.

The damage caused by a heart attack had previously been considered permanent.
But a study in the journal Nature showed the drug, thymosin beta 4, if used in advance of a heart attack, was able to "prime" the heart for repair.
The British Heart Foundation described repair as the "holy grail of heart research", but said any treatment in humans was years away.
Due to advances in health care the number of people dying from coronary heart disease is falling.
But those living with heart failure are on the rise - more than 750,000 people have the condition in the UK alone.
Wake up
The researchers at University College London looked at a group of cells which are able to transform into different types of heart tissue in an embryo.

UK Heart statistics

Deaths from coronary heart disease

• 1961 - 165,216
• 2001 - 117,743
• 2009 - 80,223

Estimated people living with heart failure

• 1961 - 100,000
• 1971 - 300,000
• 2010 - 750,000

Source: British Heart Foundation

In adults epicardium-derived progenitor cells line the heart, but have become dormant.

Scientists used a chemical, thymosin beta 4, to "wake them up".
Professor Paul Riley, from the University College London, said: "The adult epicardial cells which line the muscle of the heart can be activated, move inward and give rise to new heart muscle."
"We saw an improvement in the ejection fraction, in the ability of the heart to pump out blood, of 25%."
As well as pumping more blood, the scar tissue was reduced and the walls of the heart became thicker.
Peter Weissberg, medical director of the British Heart Foundation, said he was "very excited" about the research but warned the scale of improvement seen in animals was rarely seen in humans.

Epicardium derived progenitor cells (in red) lining the heart

However, he argued that even a small improvement would have a dramatic impact on people's quality of life.
"A normal heart has lots of spare capacity. In patients with heart failure it is working flat out just to sit down [and] it's like running a marathon," he said.
"You could turn a patient from somebody who's gasping while sitting in a chair to somebody who can sit comfortably in a chair."
Advance therapy
The mice needed to take the drug in advance of a heart attack in order for it to be effective. As the researchers put it, "the priming effect is key".
If a similar drug could be found to be effective in humans, then the researchers believe it would need to be prescribed in a similar way to statins.
Professor Riley said "I could envisage a patient known to be at risk of a heart attack - either because of family history or warning signs spotted by their GP - taking an oral tablet, which would prime their heart so that if they had a heart attack the damage could be repaired."
He said this could be available in 10 years.
The British Heart Foundation, which funded the study, said repairing a damaged heart was the "holy grail" of heart research.
The results strengthened the evidence that drugs could be used to prevent the onset of heart failure, it said.